How to Troubleshoot HPLC

This course on HPLC troubleshooting will demystify your HPLC instrument so that you can use your knowledge and understanding to interpret symptoms and thus diagnose problems, and also introduce effective preventative measures.


Learn how to find solutions for problems encountered when running HPLC analysis by diagnosing symptoms and implementing appropriate preventative measures.

The course will enable you to go back to your lab with a full understanding of why problems may arise with your HPLC system and give you the skills and knowledge to both prevent and resolve those problems.

Attendees are invited to bring along any real life examples that they would like advice on during the training. These may be discussed during group exercises, or, where intellectual property is an issue, privately with the trainer.

Total learning time = 5 hours

More about total learning time

Learning Objectives

On completion of this training course you will be able to: 

  1. Understand how HPLC works and the role of each component in a HPLC system.
  2. Understand how problems can arise in the individual components of a HPLC system.
  3. Implement measures which prevent problems occurring.
  4. Diagnose and resolve problems associated with HPLC.
How is this course delivered?

This course is delivered as a 1 day ‘virtual’ live online training event which is delivered over a 6 hour period, including breaks, typically from 9am to 3pm (but may depend on your time zone).

More about live online training

Total learning time = 5 hours

More about total learning time

The full agenda is provided in the course description.

The course may also be delivered as in-house training, either in the live online format or in a classroom based format at your site. In-house training allows customisation to meet your specific requirements.

More about in-house training

Who will deliver this training course?

All training courses are delivered by the MTS consultant, Oona McPolin. Some recordings of MTS webinars are provided below as examples of Oona’s presentation style.

Strategies for HPLC Method Development
Webinar Recording This webinar explored the different strategies, and combinations of strategies, which may be applied during HPLC method development. …
Where do the Acceptance Criteria in Method Validation Come From?
Webinar Recording One of the most difficult tasks when writing an analytical method validation protocol is to set suitable acceptance …
Who should attend this course?

Those who have experience of using HPLC and now want to develop their skills further and prevent and troubleshoot problems.

For example:

  • Analytical chemists in industry (the course is not specific to a particular industry)
  • Researchers who need to use HPLC
When can I attend this course in 2024
  • Thu 19th Apr 2024 (9am to 3pm BST/UTC+1)
  • Wed 18th Sep 2024 (9am to 3pm BST/UTC+1)
  • Wed 27th Nov 2024 (9am to 12:45pm GMT/UTC)
  • Also available as an on-demand self paced course which can be completed at a time to suit you
How much does it cost?

£275 GBP or €315 EUR

Included in your course fees:
  • Comprehensive course hand-outs – The training book is provided as an electronic copy (pdf) for both live online and classroom based options.
  • Certificate of Attendance
  • Optional post training assessment (accessed in e-MTS, our learning management system) which leads to a Certificate of Training.
  • Access to training materials via e-MTS
  • Post training support – Attendees can contact the trainer with questions that may occur when they apply their learning to real life situations.
  1. All prices are quoted per person excluding VAT.
  2. VAT notice for live online training: For UK business cutomers and non-business customers (B2C) from all countries VAT is charged at the UK rate (currently 20%). For EU business customers (B2B), the reverse charge can be applied on receipt of a valid VAT identification number and VAT will not be charged. For business customers outside of the UK and EU, VAT will not be charged.
Cancellations and Substitutions

Once made and accepted by MTS, course bookings are liable for payment. Payment is due at least 14 days prior to the course start date. Cancellations prior to 3 weeks before the course date are subject to an administration charge of 25%. Cancellations received less than 3 weeks before the start of the course will not be refunded, although substitutions may be made at any time.

We reserve the right to change the programme, speakers, date or venue without notice, or to cancel an event. In the unlikely event of cancellation occurring, delegates will be notified as soon as possible and will receive a full refund of fees paid.

What do people say about this course?
“Enjoyed the course very much. Has consolidated what I already know but also gained new and valuable information. Clear, concise and good reference material going forward. Trainer’s style and presentation good.”

M. O Loughlin, Roche

“Very good course – just what our analysts needed!!”

J. Warwick, GSK

“Very informative and could save a lot of time in future troubleshooting.”

D. Tuohy, Intertek

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