Resources

Webinars

On-demand webinar recordings:

Some recordings of MTS webinars are provided below. These are intended as useful resources but also provide a sample of the presentation style of the MTS consultant, Oona McPolin, who delivers all of our training courses.

Strategies for HPLC Method Development
Webinar Recording This webinar explored the different strategies, and combinations of strategies, which may be applied during HPLC method development. The best approach may …
Where do the Acceptance Criteria in Method Validation Come From?
Webinar Recording One of the most difficult tasks when writing an analytical method validation protocol is to set suitable acceptance criteria, particularly for the …
Books

MTS offers two books on topics relating to the chemical analysis of pharmaceuticals. The books are written by Oona McPolin, the MTS trainer and consultant. They provide practical and current information. The topics available are introductory HPLC and method validation, both applied to pharmaceutical analysis.

Cost and Shipping

Both books cost £29.00 GBP plus shipping. Shipping is FREE to UK and Ireland addresses and is very reasonably priced for other locations at only £3.50 GBP for Europe and £5.50 GBP for the rest of the world. The shipping time depends on your location and is typically less than 14 days from the date of the order, but due to the current pandemic situation it could be significantly longer.

You can purchase single or multiple copies of either book using the PayPal button provided but contact us if you would like a quotation for a larger order.

Validation Of Analytical Methods for Pharmaceutical Analysis
“A nicely written handbook on how to perform validation of methods used in pharmaceutical analysis.”

Chemistry World, Royal Society of Chemistry.

Overview

A full review of the available regulatory guidelines on validation and in particular, those from the International Conference on Harmonisation (ICH). Sections of the guideline, Q2(R1), have been reproduced in this book with the kind permission of the ICH Secretariat.

Features
  • Thorough discussion of each of the validation characteristics: Specificity; Linearity; Range; Accuracy; Precision; Detection Limit; Quantitation Limit; Robustness; System Suitability; plus practical tips on how they may be studied.
  • What to include in a validation protocol, with advice on the experimental procedure to follow and selection of appropriate acceptance criteria.
  • How to interpret and calculate the results of a validation study, including the use of suitable statistical calculations.
  • A fully explained case study demonstrating how to plan a validation study, what to include in the protocol, experiments to perform, setting acceptance criteria, interpretation of the results and reporting the study.
To purchase:
Please choose your location for shipping, then click on ‘Buy Now’

ISBN: 978-0-9561528-1-7

Format: Paperback, 210 x 300mm (A4), 152 pages

Publisher: Mourne Training Services

An Introduction to HPLC for Pharmaceutical Analysis
“A brief well-written guide and resource to assist the analyst in the use of HPLC in a pharmaceutical analysis environment.”

Chemistry World, Royal Society of Chemistry

Overview

This book is aimed at those who are new to HPLC. Whether you are a new starter in an analytical laboratory, an experienced scientist new to HPLC, a recent graduate, or a student, it provides an invaluable guide about how HPLC is actually used when analysing pharmaceuticals.

Features
  • A thorough discussion of the stationary phase enabling the reader to make sense of the many parameters used to describe a HPLC column.
  • Practical advice and helpful hints for the preparation and use of mobile phase.
  • A complete overview of each of the different components which together make up a HPLC system.
  • A description of the contents of a typical HPLC analytical method and how to interpret these.
  • A step-by-step guide on how to follow a method and set up a HPLC analysis.
  • A discussion of system suitability criteria and how to interpret the values obtained during an analysis.
  • Explanation of the common methods of calibration and quantification used for pharmaceutical analysis.
To purchase:
Please choose your location for shipping, then click on ‘Buy Now’

ISBN: 978-0-9561528-0-0

Format: Paperback, 210 x 300mm (A4), 148 pages

Publisher: Mourne Training Services Ltd

MTS Helpdesk

Our consultant will answer your questions and provide advice on your technical problems. Use our enquiry form to send us your questions. Questions and answers may end up as posts on our blog. You can use browse some previously submitted questions below.

HPLC Mobile Phase Expiry Dates
Question: What is the typical (the industrial 'norm') for the expiration date of mobile phases for HPLC, i.e. with buffer …
How Much Forced Degradation in a Stress Study?
Question: When I forcibly degrade my drug or drug product to create degradation products, how much degradation should I aim …
Need to Revalidate Method if HPLC Column is Changed?
Question: I would like to have a 'back-up' column for my HPLC method so that I am not reliant on …
What is Mass Balance in a Forced Degradation Study?
Question: What is the 'mass balance' for an analytical method and is it critical that I investigate it as part …
HPLC Calculator (Free)

The MTS HPLC calculator is in the form of an Excel spreadsheet comprised of 7 worksheets which correspond to useful HPLC related calculations.

The calculator was developed to support our HPLC training courses, ‘How to Run HPLC Methods‘, ‘How to Troubleshoot HPLC‘ and ‘How to Develop HPLC Methods‘.

It has been downloaded hundreds of times by users from all over the world. If you have any requests or feedback then please let us know.

Simply fill in and submit the Request Form below, your free HPLC calculator will be sent to you by email (so you may need to check your junk folder).

The calculations provided are as follows:

#1 Column Equilibration

For how long do you need to equilibrate a column before it is ready to use?

#2 Void Volume

Calculates the void volume and estimates the retention time of t0 (often referred to as the solvent front).

#3 Pressure Converter

Change pressure units between the most commonly used units, e.g. psi to bar

#4 Mobile Phase Buffer Strength

Performs the conversion from millimoles (mM) and %w/w to a mass and volume.

#5 Mobile Phase Quantity – Isocratic

Works out how much mobile phase you will need to prepare for an isocratic analysis.

#6 Mobile Phase Quantity – Gradient

Works out how much mobile phase you will need to prepare for a gradient analysis (one of the most popular!).

#7 Method Development

Accompanies our HPLC method development courses to provide a simple way to convert a single gradient scouting run into a prediction of best conditions for initial method development, and predict whether an isocratic or a gradient approach will be most suitable. 

Aide Mémoire for Method Transfer (Free)

The purpose of this aide mémoire is to provide a list of method features that may be important to consider during a transfer. It provides a convenient means to identify any potential issues and record the findings during a risk assessment gap analysis.

The tool was developed to support our training course on method verification and transfer. If you have any suggestions to improve the tool, then please let us know.

Simply fill in and submit the Request Form below, your free aide mémoire will be sent to you by email (so you may need to check your junk folder).

Request Form

Simply complete the form below if you would like to request our HPLC Calculator and/or the Aide Mémoire for Method Transfer. The files will be sent to you by email (so you may need to check your junk folder).